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Literature summary extracted from

  • Abid, K.; Rochat, B.; Lassahn, P.G.; Stoecklin, R.; Michalet, S.; Brakch, N.; Aubert, J.F.; Vatansever, B.; Tella, P.; De Meester, I.; Grouzmann, E.
    Kinetic study of neuropeptide Y (NPY) proteolysis in blood and identification of NPY3-35: a new peptide generated by plasma kallikrein (2009), J. Biol. Chem., 284, 24715-24724.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.21.34 0.0281
-
 neuropeptide Y3-36 at 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.34 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.34
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.34 blood plasma
-
 Homo sapiens
-
3.4.21.34 serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.34 neuropeptide Y3-36 + H2O optimal kallikrein concentration is 5 microg/ml, cleavage of around 70% of neuropeptide Y3-36. Higher concentrations of kallikrein conversely results in a decrease of NPY3-35 levels without an increase of neuropeptide Y3-36 levels, suggesting that high concentrations of kallikrein enable additional and nonspecific neuropeptide Y cleavages Homo sapiens neuropeptide Y3-35 + L-tyrosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.34 kallikrein
-
 Homo sapiens
3.4.21.34 plasma kallikrein
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.34 physiological function plasma kallikrein is the carboxypeptidase/esterase enzyme responsible for tyrosinamide removal from neuropeptide Y Homo sapiens